// NFL · Week 10 · Sunday 15 November 2026
San Francisco 49ers vs Dallas Cowboys prediction
Kick-off 4:25pm ET ·
- Pick
- San Francisco 49ers
- Chance
- 65%
- Light
- Green
- Confidence
- High
Full breakdown: team stats, players & form →
Injury report
San Francisco 49ers
- Brandon Aiyuk WR · Out · Personal (8 Nov, 3:58 am AEDT)
- Mike Evans WR · Out · Achilles (7 Nov, 9:05 am AEDT)
- Deebo Samuel Sr. WR · Out · Hamstring (7 Nov, 8:06 am AEDT)
- Nate Hobbs CB · Injured reserve · Groin (8 Nov, 12:27 pm AEDT)
- Christian Kirk WR · Injured reserve · Knee - Meniscus (8 Nov, 8:50 am AEDT)
- De'Zhaun Stribling WR · Injured reserve · Ankle (3 Nov, 9:05 am AEDT)
- Siran Neal S · Questionable · Knee (5 Nov, 10:29 am AEDT)
- Upton Stout CB · Questionable · Shoulder - AC Joint (27 Oct, 10:07 am AEDT)
- KhaDarel Hodge WR · Returning (8 Nov, 12:20 pm AEDT)
- Demarcus Robinson WR · Returning (8 Nov, 8:44 am AEDT)
- Garret Wallow LB · Returning (7 Nov, 3:37 pm AEDT)
- Luke Gifford LB · Returning (7 Nov, 3:30 pm AEDT)
- +13 more
Dallas Cowboys
- KaVontae Turpin WR · Out · Ribs (7 Nov, 11:19 am AEDT)
- Jonathan Bullard DT · Injured reserve · Calf (8 Nov, 1:22 pm AEDT)
- Malachi Lawrence LB · Injured reserve · Ankle (8 Nov, 9:30 am AEDT)
- Jalen Thompson S · Injured reserve · Hamstring (5 Nov, 2:45 pm AEDT)
- Marist Liufau LB · Questionable · Forearm (8 Nov, 1:15 pm AEDT)
- Joey Porter Jr. CB · Questionable · Ankle (7 Nov, 11:43 am AEDT)
- DeMarvion Overshown LB · Questionable · Hamstring (7 Nov, 11:32 am AEDT)
- Jake Ferguson TE · Questionable · Ankle (7 Nov, 7:13 am AEDT)
- George Pickens WR · Questionable · Hamstring (7 Nov, 7:09 am AEDT)
- Luke Schoonmaker TE · Questionable · Groin (4 Nov, 12:03 am AEDT)
- Jordan Hudson WR · Returning (8 Nov, 9:51 am AEDT)
- James Mitchell TE · Returning (8 Nov, 9:40 am AEDT)
- +13 more
● Out● May miss / reduced minutes● Probable / returning
Statuses from the official team injury reports. Updated 8 Nov, 5:20 pm AEDT; refreshed every 15 minutes.
Preview
San Francisco 49ers are our pick on the road against the Dallas Cowboys in Week 10. The model gives them a 65% chance of winning, which makes this game a 65%+ top pick.
San Francisco 49ers have the higher team rating (1637 to 1440), built from results and winning margins.
Quarterbacks: we expect Brock Purdy to start for San Francisco 49ers (60 career starts); we expect Dak Prescott to start for Dallas Cowboys (153 career starts). We assume each team's most recent starter plays unless the injury report says otherwise.
Season so far: San Francisco 49ers are 6–1 and Dallas Cowboys are 3–5.
What could change the pick: late quarterback news. We re-check every 30 minutes until kick-off, then the pick is frozen and stays on our public record, win or lose.
This is one of our top picks: San Francisco 49ers at 65% to win.
More NFL predictions that day
- Sun, 15 NovNew England Patriots @ Detroit Lions NE 62%Orange
- Sun, 15 NovMiami Dolphins @ Indianapolis Colts IND 60%Orange
- Sun, 15 NovBuffalo Bills @ New York Jets BUF 79%Green
- Sun, 15 NovCarolina Panthers @ New Orleans Saints NO 55%Orange
- Sun, 15 NovHouston Texans @ Cleveland Browns HOU 55%Orange
- Sun, 15 NovJacksonville Jaguars @ Tennessee Titans JAX 79%Green
- Sun, 15 NovKansas City Chiefs @ Atlanta Falcons KC 53%Red
- Sun, 15 NovMinnesota Vikings @ Green Bay Packers GB 59%Orange
- Sun, 15 NovLos Angeles Rams @ Arizona Cardinals LA 70%Green
- Sun, 15 NovSeattle Seahawks @ Las Vegas Raiders SEA 57%Orange
- Sun, 15 NovPittsburgh Steelers @ Cincinnati Bengals CIN 52%Red
Probabilities come from ProbaLab's own model. They are for entertainment, not advice. How it works.